34ßE12 recognizes cytokeratin (CK) 1,
5, 10 and 14. This antibody is reactive with squamous and adeno-squamous
carcinomas; adenocarcinomas are negative. In normal epithelia, 34betaE12
stains stratified epithelia, myoepithelial cells and basal cells in the prostate
gland and bronchi. 34betaE12 is useful as a differential marker for squamous
carcinomas and adenocarcinomas as well as for benign and malignant tumors of the
prostate gland.